| Bioactivity | Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. | ||||||||||||
| Target | IC50: 0.65 μM (IGF1R). | ||||||||||||
| Invitro | Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1]. | ||||||||||||
| Name | Indirubin Derivative E804 | ||||||||||||
| CAS | 854171-35-0 | ||||||||||||
| Formula | C20H19N3O4 | ||||||||||||
| Molar Mass | 365.38 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962. |
Indirubin Derivative E804
CAS: 854171-35-0 F: C20H19N3O4 W: 365.38
Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65
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