| Bioactivity | Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5]. |
| Invitro | Imipramine (0.5-300 μM, 3 days) inhibits HCT-116 cell viability[1].Imipramine (20 μM) inhibits cell migration (7 h) and invasion (48 h)[1].Imipramine (50 μM, 0-240 min) inhibites the PI3K/Akt/mTOR signaling pathway in U-87MG glioma cells[2].Imipramine (60 μM, 24 h) stimulates U-87MG glioma cells autophagy[2].Imipramine (80 μM, 24 h) induces HL-60 cell apoptosis[3]. Cell Viability Assay[1] Cell Line: |
| Name | Imipramine |
| CAS | 50-49-7 |
| Formula | C19H24N2 |
| Molar Mass | 280.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |