| Bioactivity | Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2]. | ||||||||||||
| Invitro | Half-life of Imazamox in the soil ranges from 1 to 3 months exhibit low mammalian toxicity[1]. Plants are treated with Imazamox (250 μM) in the nutrient solution and harvested 7 days after. Imazamox is mainly accumulated in V. sativa, six fold higher than those detected in P.vulgaris[3]. | ||||||||||||
| In Vivo | Imazamox (12-36 mg/kg; intraperitoneal injection; for 24-72 hours; male Sprague-Dawley rats) treatment induces toxic effects in the liver and pancreas of Sprague Dawley rats. Necrotic and degenerative changes are detected in hepatocytes at the two highest doses. Imazamox treatment reduces the size of the β-islet cells, and also induces an elevation in serum glucose and calcium[4]. Animal Model: | ||||||||||||
| Name | Imazamox | ||||||||||||
| CAS | 114311-32-9 | ||||||||||||
| Formula | C15H19N3O4 | ||||||||||||
| Molar Mass | 305.33 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wei J et al. Enantioselective Phytotoxicity of Imazamox Against Maize Seedlings. Bull Environ Contam Toxicol. 2016 Feb;96(2):242-7. [2]. García-Garijo A, et al. Metabolic responses in root nodules of Phaseolus vulgaris and Vicia sativa exposed to the imazamox herbicide. Pestic Biochem Physiol. 2014 May;111:19-23. [3]. Imazamox Chemical Fact Sheet. Wisconsin Department of Natural Resources. DNR PUB-WT-974 2012. [4]. Sevim Ç, et al. An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas. Toxicol Rep. 2018 Nov 19;6:42-50. |