| Bioactivity | Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM)[1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier. | ||||||||||||
| Invitro | Idebenone, a compound with protective efficacy against neurotoxicity both in in vitro and in in vivo models, exists in two different oxidative states: the ubiquinol-derivative (reduced idebenone) and the ubiquinone-derivative (oxidised idebenone)[1]. Idebenone (oxidised form) preferentially inhibits cyclooxygenase vs. lipoxygenase metabolism (IC50 ratio lipoxygenase/cyclooxygenase: 3.22)[1].Idebenone (oxidised form) behaves similarly as indomethacin and piroxicam—two typical anti-inflammatory agents[1].Idebenone (oxidised form) inhibits total arachidonic acid metabolism, cyclooxygenase metabolism, lipoxygenase metabolism, lipoxygenase/cyclooxygenase with IC50s of 16.65±3.48, 14.44±2.99, 46.51±7.20, and 3.22 μM[1].Idebenone (1-10 μM; for 24-72 h) has no effect on the cell viability of SHSY-5Y cells[2].Idebenone (25 μM or higher concentrations; for 24-72 h) shows significant reduction in cell viability of SHSY-5Y cells[2]. Idebenone (30 μM) induces up-regulation of BAX expression and the caspase-3 activity[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Idebenone | ||||||||||||
| CAS | 58186-27-9 | ||||||||||||
| Formula | C19H30O5 | ||||||||||||
| Molar Mass | 338.44 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|