| Bioactivity | Idasanutlin-d3 (RG7388-d3) is the deuterium labeled Idasanutlin (HY-15676). Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM[1][2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| Name | Idasanutlin-d3 |
| Formula | C31H26D3Cl2F2N3O4 |
| Molar Mass | 619.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |
Idasanutlin-d3
CAS: F: C31H26D3Cl2F2N3O4 W: 619.50
Idasanutlin-d3 (RG7388-d3) is the deuterium labeled Idasanutlin (HY-15676). Idasanutlin (RG7388) is a potent and selecti
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