| Bioactivity | Idasanutlin enantiomer is the inactive isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM. |
| Name | Idasanutlin (enantiomer) |
| Formula | C31H29Cl2F2N3O4 |
| Molar Mass | 616.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ding Q, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56(14):5979-83. [2]. Higgins B, et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014, 20(14), 3742-3752. |
Idasanutlin (enantiomer)
CAS: F: C31H29Cl2F2N3O4 W: 616.48
Idasanutlin enantiomer is the inactive isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Ida
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