| Bioactivity | Idalopirdine (Lu AE58054 ) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders[1][2]. |
| In Vivo | Idalopirdine (intraperitoneal injection, 5 mg/kg, daily, 28 days) can reduce food intake and body weight in over-eating rat models[1].Idalopirdine (1 or 2 mg/kg, i.v) can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats[2]. Animal Model: |
| Name | Idalopirdine |
| CAS | 467459-31-0 |
| Formula | C20H19F5N2O |
| Molar Mass | 398.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Magdalena Kotańska, et al. Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating. Metab Brain Dis. 2018 Jun;33(3):733-740. [2]. Maria Amat-Foraster, et al. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture. Neuropharmacology. 2017 Feb;113(Pt A):45-5 |
Idalopirdine
CAS: 467459-31-0 F: C20H19F5N2O W: 398.37
Idalopirdine (Lu AE58054 ) is a potent, selective 5-HT6 receptorantagonist with a Ki value of 0.83 nM. Idalopirdine may
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