| Bioactivity | IXA6 is a novel IRE1/XBP1s activator, and can induce IRE1 RNase activity[1]. |
| Invitro | IXA6 (10 µM; 4 or 18 h) selectively activates IRE1-XBP1s signaling, and activates the XBP1s transcriptional response[1].IXA6 (10 µM; 4 h) shows selectivity for IRE1-XBP1s-dependent ER proteostasis remodeling[1].IXA6 (10 µM; 18 h) reduces secretion of APP through IRE1 activation[1]. Western Blot Analysis[1] Cell Line: |
| Name | IXA6 |
| CAS | 1021106-40-0 |
| Formula | C22H20ClN3O3S |
| Molar Mass | 441.93 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Julia M D Grandjean, et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nat Chem Biol. 2020 Oct;16(10):1052-1061. |