| Bioactivity | IWP-051 is an agonist for soluble guanylate cyclase with an EC50 of 290 nM. IWP-051 stimulates the generation of cGMP, and exhibits the synergistic effect with NO. IWP-051 exhibits good pharmacokinetic characteristics in rats[1]. |
| Target | EC50: 290 nM (soluble guanylate cyclase) |
| CAS | 1354041-91-0 |
| Formula | C17H11F2N5O2 |
| Molar Mass | 355.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nakai T, et al., Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans. ACS Med Chem Lett. 2016 Feb 24;7(5):465-9. |
IWP-051
CAS: 1354041-91-0 F: C17H11F2N5O2 W: 355.30
IWP-051 is an agonist for soluble guanylate cyclase with an EC50 of 290 nM. IWP-051 stimulates the generation of cGMP, a
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