| Bioactivity | ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1]. |
| Invitro | ITK antagonist inhibits DT40 cell (IC50=4 nM) and shows IL-2 inhibition (IC50=20 nM)[1]. |
| Name | ITK antagonist |
| CAS | 1149753-56-9 |
| Formula | C26H34N6O2S |
| Molar Mass | 494.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Riether D, et al. 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett. 2009;19(6):1588-1591. |
ITK antagonist
CAS: 1149753-56-9 F: C26H34N6O2S W: 494.65
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) anta
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