| Bioactivity | ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2]. |
| Name | ITH12575 |
| CAS | 1802013-08-6 |
| Formula | C18H18ClNOS |
| Molar Mass | 331.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Francisco J Martínez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. [2]. Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. |
ITH12575
CAS: 1802013-08-6 F: C18H18ClNOS W: 331.86
ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at
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