| Bioactivity | ISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPARγ. ISX-3 has the potential for the research of osteopenia and osteoporosis[1]. |
| Invitro | ISX-3 (0-100,000 nM; 10 days) 显示出对脂滴积累的刺激作用和对 ALP 诱导的抑制作用[1]。ISX-3 (50 µM; 2 days) 在存在 MDI 的情况下增加 hBMSCs 中 PPARγ 的表达[1]。 Western Blot Analysis[1] Cell Line: |
| Name | ISX-3 |
| CAS | 912789-08-3 |
| Formula | C16H15ClN4O2 |
| Molar Mass | 330.77 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Nawa K, et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74. |