| Bioactivity | ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis[1]. |
| Target | IC50: 1.9 μM (lipid droplet formation); EC50: 1.2 μM (induce ALP) |
| Invitro | ISX-1 剂量依赖性地抑制细胞内脂滴的积累并刺激 ALP 活性[1]。ISX-1 可形成脂滴，IC50 值为 1.9 μM，也可诱导 ALP，EC50 值为 1.2 μM[1]。ISX-1（0、1.3、6.5 和 33 μM；3 天）抑制 hBMSCs 成脂分化过程中 PPARγ 和 FABP4 基因的 mRNA 诱导[1]。ISX-1（0、1.3、6.5 和 33 μM）促进 TCF/LEF 介导的基因转录[1]。 RT-PCR[1] Cell Line: |
| Name | ISX-1 |
| CAS | 909207-35-8 |
| Formula | C14H14N4O2S |
| Molar Mass | 302.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nawa, Katsuhiko et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74. |