| Bioactivity | ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2]. | |||||||||
| Invitro | ISPA-28 is only effective as an inhibitor of Dd2 channels (K0.5 values of 56 nM and 43 μM for Dd2 and HB3 channels, respectively)[2]. | |||||||||
| Name | ISPA-28 | |||||||||
| CAS | 1006335-39-2 | |||||||||
| Formula | C21H24N6O3 | |||||||||
| Molar Mass | 408.45 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes. [2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels. |