| Bioactivity | ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1]. |
| Invitro | ISAM-140 (22b) (0.1-100 µM) inhibits NECA (5'-N-ethylcarboxamido adenosine)-stimulated cAMP accumulation[1].ISAM-140 shows a KB value of 27.00 nM[1]. |
| Name | ISAM-140 |
| CAS | 932191-62-3 |
| Formula | C19H19N3O3 |
| Molar Mass | 337.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. El Maatougui A, et al. Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. J Med Chem. 2016 Mar 10;59(5):1967-83. |