IRF1-IN-2_product_DataBase

Bioactivity	IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].
Invitro	IRF1-IN-2 (20 μM, 12 h) 预处理可减少辐照的 HaCaT 细胞 (20 Gy) 中 IRF1 对 CASP1 启动子的招募[1]。IRF1-IN-2 (20 μM, 24 h) 可减弱 HELF 和 WS1 细胞中 NSP-10 质粒转染诱导的 IRF1 激活[1]。IRF1-IN-2 保护 A375 细胞免受辐射 (20 Gy) [1]。IRF1-IN-2 可抑制细胞死亡信号通路，包括抑制 Caspase 1、GSDMD、IL-1 和 PARP1 的裂解，TKB1 的磷酸化，上调 GPX4 和下调 FACL4[1]。IRF1-IN-2 在辐照后的早期阶段维持皮肤细胞线粒体的活性和 ROS 的产生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IRF1-IN-2 相关抗体:
In Vivo	IRF1-IN-2 预处理 (100 μg/d，皮下注射，隔天一次照射) 对 35 Gy 辐射诱导的炎症性皮肤损伤小鼠具有潜在的保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	708245-32-3
Formula	C18H20N2O4S
Molar Mass	360.43
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Geng, et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024 Aug;21(8):856-872.

PeptideDB

IRF1-IN-2

CAS: 708245-32-3 F: C18H20N2O4S W: 360.43