IRAK4-IN-20

CAS: 1931994-80-7 F: C22H25F3N4O3 W: 450.45

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research[1].
Invitro	IRAK4-IN-20 (Compound BAY-1834845) (500 nM, 20 h) decreases inflammatory cytokines secretion effectively in an in vitro treatment of LPS stimulated human peripheral blood mononuclear cells (PBMC)[1].
In Vivo	IRAK4-IN-20 (Compound BAY-1834845) (150 mg/kg; p.o.; once or twice) effectively prevents acute respiratory distress syndrome in mice[1]. Animal Model:
Name	IRAK4-IN-20
CAS	1931994-80-7
Formula	C22H25F3N4O3
Molar Mass	450.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Q, et al. Oral IRAK4 Inhibitor BAY-1834845 Prevents Acute Respiratory Distress Syndrome. Biomedicine & Pharmacotherapy, 2022: 113459.