| Bioactivity | IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, with an IC50 of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK1/4/pan-FLT3 Kinase-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432)[1]. |
| CAS | 2760328-82-1 |
| Formula | C21H26FN5O2 |
| Molar Mass | 399.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hoyt SB, et al. Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia. ACS Med Chem Lett. 2024 Oct 23;15(11):1843-1851. |
IRAK1/4/pan-FLT3 Kinase-IN-1
CAS: 2760328-82-1 F: C21H26FN5O2 W: 399.46
IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, with an IC50 of 5 nM
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.