| Bioactivity | IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM. | ||||||||||||
| Target | IC50: 160 nM (IRAK-4) | ||||||||||||
| Invitro | IRAK inhibitor 6 significantly improves potency against IRAK-4. Potency effects additive, IRAK inhibitor 6 is the most active compound among these compound tested[1]. | ||||||||||||
| Name | IRAK inhibitor 6 | ||||||||||||
| CAS | 1042672-97-8 | ||||||||||||
| Formula | C20H20N4O3S | ||||||||||||
| Molar Mass | 396.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Buckley G, et al. IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. |