IRAK-4 protein kinase inhibitor 2_product_DataBase

CAS: 301675-24-1 F: C14H10N4O3 W: 282.25

IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-

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Bioactivity

IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1].

Invitro

IRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC50 of <10 μM[1].

Name

IRAK-4 protein kinase inhibitor 2

CAS

301675-24-1

Formula

C14H10N4O3

Molar Mass

282.25

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.

PeptideDB

IRAK-4 protein kinase inhibitor 2

CAS: 301675-24-1 F: C14H10N4O3 W: 282.25