| Bioactivity | IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway[1]. |
| Name | IR-58 |
| CAS | 2374274-85-6 |
| Formula | C58H82BrClN4O6 |
| Molar Mass | 1046.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yinghui Huang, et al. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018 Feb;67(2):307-319. |
IR-58
CAS: 2374274-85-6 F: C58H82BrClN4O6 W: 1046.65
IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and
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