| Bioactivity | IP3RCYT is IP3R inhibitory peptide, which can inhibit the binding of cytochrome C to IP3R with an IC50 about 100 nM. IP3RCYT regulates calcium signaling within cells. P3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with Staurosporine (HY-15141) or Membrane-bound Fas ligand (FasL)[1]. |
| Sequence | Asp-Asn-Lys-Thr-Val-Thr-Phe-Glu-Glu-His-Ile-Lys-Glu-Glu-His-Asn-Cys |
| Shortening | DNKTVTFEEHIKEEHNC |
| Formula | C87H133N25O32S |
| Molar Mass | 2073.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Boehning D, et al. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1466-71. |