IOX2 sodium_product_DataBase

Bioactivity	IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases[1][2].
Target	IC50: 22 nM (PHD2)
Invitro	IOX2 sodium (0、10、25 和 50 μM) 剂量依赖性地抑制胶原蛋白相关肽 (CRP；0.25μg/mL) 或凝血酶 (0.03 U/mL) 诱导的血小板聚集和 ATP 释放。但 IOX2 不影响 P-选择素表达和糖蛋白 (GP)Ibα、GPVI 或 αIIbβ3 的表面水平[1]。IOX2 sodium 还抑制血小板在纤维蛋白原或胶原蛋白上的扩散和凝块回缩[1]。IOX2 sodium (50 μM；24 h) 增加正常人的表皮角质形成细胞 (NHEK) 和正常人真皮成纤维细胞 (NHDF) 在常氧和缺氧条件下生长时 VEGF-A 和 BNIP3 的转录水平[2]。
In Vivo	IOX2 sodium (10 mg/kg；腹腔注射；单剂量) 损害小鼠体内血小板的止血功能和动脉血栓形成[1]。 Animal Model:
Name	IOX2 sodium
CAS	2377239-85-3
Formula	C19H15N2NaO5
Molar Mass	374.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gu W, et al. Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function. Thromb Haemost. 2022 Oct;122(10):1693-1705. [2]. Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50.

PeptideDB

IOX2 sodium

CAS: 2377239-85-3 F: C19H15N2NaO5 W: 374.32