| Bioactivity | IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 µM. IOWH-032 also is a anti-diarrheal agent[1][2]. | ||||||||||||
| Invitro | IOWH-032 (10 µM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | IOWH-032 | ||||||||||||
| CAS | 1191252-49-9 | ||||||||||||
| Formula | C22H15Br2N3O4 | ||||||||||||
| Molar Mass | 545.18 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation [2]. de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25. [3]. Lotti V, et al. CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells. Cells. 2022 Apr 15;11(8):1347. [4]. Thiagarajah JR, et al. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep;92(3):287-90. |
IOWH-032
CAS: 1191252-49-9 F: C22H15Br2N3O4 W: 545.18
IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 µM. IOWH-032 also
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