| Bioactivity | INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1]. | ||||||||||||
| In Vivo | INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1]. Animal Model: | ||||||||||||
| Name | INH14 | ||||||||||||
| CAS | 200134-22-1 | ||||||||||||
| Formula | C15H16N2O | ||||||||||||
| Molar Mass | 240.30 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717. |