| Bioactivity | INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity[1][2]. |
| Invitro | INCB9471 (0-1 µM) 抑制 MIP-1 诱导的 rhIL-10 处理的人类单核细胞趋化性，IC50 值为 4.8 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> INCB9471 相关抗体: |
| In Vivo | 药代动力学[2]. |
| CAS | 869769-98-2 |
| Formula | C30H40F3N5O2 |
| Molar Mass | 559.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shin N, et al. Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection. J Pharmacol Exp Ther. 2011 Jul;338(1):228-39. [2]. Xue CB, et al. Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity. ACS Med Chem Lett. 2010 Aug 25;1(9):483-7. |