INCB059872 dihydrochloride_product_DataBase

Bioactivity	INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia[1].
Invitro	INCB059872 (25 nM; 48 小时; 293T 细胞) dihydrochloride 增加增强子活性和基因表达[1]。INCB059872 (25 nM; 48 小时; THP-1 细胞) dihydrochloride 使 THP-1 在一个细胞倍增时间内或大约 3 天内显示出生长缺陷[1]。INCB059872 (THP-1 细胞) dihydrochloride 调节 PRO-seq 分析鉴定基因和增强子[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 天; C57BL/6J 小鼠) dihydrochloride 使单细胞 RNA-seq 显示骨髓祖细胞群[1]。 Animal Model:
Name	INCB059872 dihydrochloride
Formula	C23H36Cl2N2O3
Molar Mass	459.45
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758.

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