| Bioactivity | IMM-01 is a formin agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects[1]. |
| Invitro | IMM-01（100 μM；1 小时）可诱导 SW480 结肠癌细胞中的微管稳定[1]。IMM-01 (10 μM) 显着诱导 NIH 3T3-SRE-LacZ 细胞中 LacZ 的表达[1]。IMM-01（1-100 μM；48 小时）在 NIH 3T3 细胞和 SW480 细胞凋亡诱导过程中诱导 caspase-3 裂解[1]。 Apoptosis Analysis[1] Cell Line: |
| In Vivo | IMM-01（5-25 mg/kg；静脉注射；每周 2 次；持续 3 周）能够减缓结肠癌小鼠异种移植模型中的肿瘤生长[1]。 Animal Model: |
| Name | IMM-01 |
| CAS | 218795-74-5 |
| Formula | C12H17N3O2S |
| Molar Mass | 267.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. L Leanne Lash, et al. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73(22):6793-803. |