| Bioactivity | IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer[1]. |
| Invitro | IL17A-IN-1 抑制 Hela 细胞的 IC50 值为 0.005 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IL17A-IN-1 相关抗体: |
| In Vivo | IL17A-IN-1 (10 mg/kg; p.o.; single dose) 可抑制 hIL17A 诱导小鼠 (含有 IL17 受体的小鼠) CXCL1 PD 模型中血浆 CXCL1 的分泌[1]。(小鼠皮下注射重组人 IL17A 能诱导血浆 CXCL1 分泌)。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C30H35Cl2N7O3 |
| Molar Mass | 612.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ramos AL, et al. Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J Med Chem. 2024 Apr 4. |