| Bioactivity | IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM[1]. | ||||||||||||
| Target | EC50: 1.81 µM (IL-4). | ||||||||||||
| Invitro | IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context[1].IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 µM, but did not affect the levels of STAT-6[1]. | ||||||||||||
| Name | IL-4-inhibitor-1 | ||||||||||||
| CAS | 1332184-63-0 | ||||||||||||
| Formula | C18H12FN3O2 | ||||||||||||
| Molar Mass | 321.31 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654. |