| Bioactivity | IKZF3 degrader 1 (compound 19a) is an IKZF3 degrader (EC50=0.012 μM, 9.2% Ymin). IKZF3 degrader 1 promotes the binding of IKZF3 to Cereblon (CRBN), leading to the ubiquitination and degradation of IKZF3[1]. |
| Formula | C25H18BrCl3N2O5 |
| Molar Mass | 612.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tracy, et al. "Asymmetric Dirhodium-Catalyzed Modification of Immunomodulatory Imide Drugs and Their Biological Assessment." ACS Medicinal Chemistry Letters (2024). |