| Bioactivity | IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits[1][2][3]. | ||||||
| Invitro | 在一个典型途径中，NF-κB 的激活依赖于 IKK 复合体的活性，该复合体由三个亚基 (IKKκ、IKKβ 和 IKKγ/NEMO) 组成，因此，KKγ NBD 抑制肽TFA 抑制 TNF-α 诱导的 NF- kb激活[2]。IKKγ NBD 抑制肽 TFA (10 μM; 90 min) 能够阻碍 Doxorubicin (HY-15142A) 诱导 (15 μM;4 h) 的 BT-474 细胞中 p65 磷酸化[2]。IKKγ NBD 抑制肽 TFA (10 μM; 48 h) 对BT-474细胞活力有轻微抑制作用，而对 Doxorubicin 的效力有增强作用[2]。 | ||||||
| Name | IKKγ NBD Inhibitory Peptide TFA | ||||||
| Shortening | DRQIKIWFQNRRMKWKKTALDWSWLQTE | ||||||
| Formula | C172H260N49F3O44S1 | ||||||
| Molar Mass | 3807.32 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
IKKγ NBD Inhibitory Peptide TFA
CAS: F: C172H260N49F3O44S1 W: 3807.32
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts
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