| Bioactivity | IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC50 value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis[1]. |
| In Vivo | IKKβ-IN-3 (Compound hit4) (10, 30 mg/kg; 1次，14天) 在完全 Freund 佐剂诱导的关节炎（AIA）大鼠模型中具有减轻炎症的作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C18H27NO4 |
| Molar Mass | 321.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li L, et al. The discovery of a novel IκB kinase β inhibitor based on pharmacophore modeling, virtual screening and biological evaluation. Future Med Chem. 2024;16(6):531-544. |