| Bioactivity | IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. | ||||||||||||
| Invitro | IITZ-01 (0-2 μM, 24 h) enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | IITZ-01 | ||||||||||||
| CAS | 1807988-47-1 | ||||||||||||
| Formula | C26H23FN8O | ||||||||||||
| Molar Mass | 482.51 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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