| Bioactivity | IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H+ reverse transporter activity. [1]. |
| Invitro | IITR08367 (0-50 μM) 浓度依赖性的增强了 Fosfomycin 对 AbaF 表达菌株大肠杆菌的活性。在浓度 50 μM时使 Fosfomycin 的 抗生素后效应增加了 30 分钟[1]。IITR08367 (25 μM; 16 min) 破坏了膜上的 H+ 梯度，最终抑制了 H+ 梯度驱动的外排泵，且不引起膜损伤[1]。IITR08367 (100 μM; 12 h) 和 Fosfomycin (64 mg/L) 和联合应用可以抑制 A. baumannii RPTC-15 生长[1]。IITR08367 (100 μM) 可在加入或不加入 Fosfomycin 的情况下消除 A. baumannii 的生物膜形成能力[1]。IITR08367 (12.5-200 μM) 对红细胞没有任何毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IITR08367 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | IITR08367 (i.p.; 30 mg/kg; 每12小时一次，持续54小时) 和 Fosfomycin 联合用药使尿路感染小鼠表现出显著改善了 A. baumannii RPTC-15 造成的损伤，组织超微结构与未感染的小鼠相似[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C16H18S2 |
| Molar Mass | 274.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Saini M, et al. Small Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against Acinetobacter baumannii by Efflux Pump Inhibition. ACS Infect Dis. 2024 Apr 1. |