| Bioactivity | IHMT-EZH2-426 (compound 38) is a potent and covalent EZH2 degrader with IC50s of 1.3 nM, 1.2 nM, and 1.7-3.5 nM against EZH2 wild-type, EZH2-A687V, and EZH2-Y641F/Y641N/Y641S, respectively. IHMT-EZH2-426 exhibits potent antiproliferation effects against both B-cell lymphoma and triple negative breast cancer (TNBC) cell lines by reducing the levels of H3K27me3 and EZH2[1]. |
| Name | IHMT-EZH2-426 |
| Formula | C31H35FN4O4S |
| Molar Mass | 578.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bin Zhou, et al. Discovery of dihydropyridinone derivative as a covalent EZH2 degrader. Eur J Med Chem. 2023 Oct 2:261:115825. |