| Bioactivity | IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1]. | |||||||||
| Invitro | IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1]. | |||||||||
| Name | IGS-1.76 | |||||||||
| CAS | 313480-47-6 | |||||||||
| Formula | C22H18N2OS | |||||||||
| Molar Mass | 358.46 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14 |