IDR-1018

CAS: 1453221-07-2 F: C71H126N26O12 W: 1535.93

IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epid

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate)[1][2].
Invitro	IDR-1018 调节中性粒细胞粘附和活化标志物的表达[3]。IDR-1018 它是迄今最有效的趋化因子诱导剂，并且在小鼠模型中表现出抗感染和抗炎活性，包括在与标准一线抗疟疾药物联合使用时对Plasmodium berghei ANKA脑疟疾的治疗有效性[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IDR-1018 相关抗体:
CAS	1453221-07-2
Sequence	Val-Arg-Leu-Ile-Val-Ala-Val-Arg-Ile-Trp-Arg-Arg-NH2
Shortening	VRLIVAVRIWRR-NH2
Formula	C71H126N26O12
Molar Mass	1535.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hashem Etayash, Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response. J. Med. Chem. 2021, 64, 22, 16854-16863. [2]. Hashem Etayash, et al. Correction to “Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response”. J. Med. Chem. 2022, 65, 3, 2710-2711. [3]. François Niyonsaba, et al. The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions. J Leukoc Biol. 2013 Jul;94(1):159-70.

22:0 Coenzyme A triammonium

NAMPT activator-7