| Bioactivity | IDO1/TDO-IN-7 (compound 43b), a isoquinoline derivative, is a potent dual IDO1/TDO inhibitor, with IC50s of 0.31 μM and 0.08 μM, respectively. IDO1/TDO-IN-7 displays acceptable pharmacokinetic profiles and potent antitumor efficacy with low toxicity in B16-F10 tumor model[1]. |
| Target | IC50: 0.31 μM (IDO1) and 0.08 μM (TDO) |
| Formula | C17H13F3N2O4S |
| Molar Mass | 398.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lin Z, et, al. Discovery, synthesis and biological evaluation of novel isoquinoline derivatives as potent indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase dual inhibitors. Eur J Med Chem. 2024 Sep 12:279:116852. |