| Bioactivity | IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC50 = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice[1]. |
| Invitro | IDO1-IN-21 (0-50 μM; 48 h) 抑制 SW480 细胞活力，其 IC50 值为 28.64 μM[1]。IDO1-IN-21 (0-10 μM; 48 h) 抑制 HeLa 细胞的 IDO1，其 IC50 值为 1.04 μM[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | IDO1-IN-21 (50, 100 mg/kg; i.p.; every three day for 21 consecutive days) 抑制 CT26 荷瘤小鼠的肿瘤生长[1]。 Animal Model: |
| Name | IDO1-IN-21 |
| CAS | 2892432-98-1 |
| Formula | C21H19F2N3O6S |
| Molar Mass | 479.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang K, et al. Discovery of novel sulfonamide chromone-oxime derivatives as potent indoleamine 2,3-dioxygenase 1 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115349. |
IDO1-IN-21
CAS: 2892432-98-1 F: C21H19F2N3O6S W: 479.45
IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC50 = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice.
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