IDH1 Inhibitor 9_product_DataBase

Bioactivity	IDH1 Inhibitor 9 (compound 11S) is a potent IDH1 inhibitor with IC50 values of 124.4, 95.7 nM for IDH1 R132H, IDH1 R132C, respectively. IDH1 Inhibitor 9 induces apoptosis and cell cycle arrest at the S phase. IDH1 Inhibitor 9 shows anti-tumor activity[1].
Invitro	IDH1 Inhibitor 9 (compound 11S) (2, 4, 8, 10 µM) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞于 S 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IDH1 Inhibitor 9 相关抗体: Apoptosis Analysis[1] Cell Line:
In Vivo	IDH1 Inhibitor 9 (20, 40 mg/kg; i.p.; every 2 days for 8 days) 对 IDH1 突变癌症模型表现出抗肿瘤活性[1]。药代动力学参数 (SD 大鼠)[1]。 Parameters
CAS	3037967-71-5
Formula	C26H30N4O3
Molar Mass	446.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xu T, et al. Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study. Eur J Med Chem. 2024 Jun 17;275:116610.

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