| Bioactivity | IDD-8E is an effective anti-pseudomonal agent (MIC =4.4 µM ) with no cytotoxicity. IDD-8E shows significant pseudomonal killing and disruption of pseudomonal biofilm. IDD-8E binds to the ATP-binding pocket of WaaP and also inhibits other ESKAPE pathogens. [1] |
| Invitro | IDD-8E (10-100 µM; 24h) 使用 RAW 细胞，在较高的浓度下，IDD-8E 的细胞存活率与未经治疗的对照相比保持不变，表明没有细胞毒性[1]。IDD-8E (2, 4.4 µM; 0-8 h) 观察到铜绿假单胞菌数量明显减少,与 Rifampicin (HY-B0272) 一样有效，抑制了假单胞菌生长。并且发现具有破坏生物膜的能力[1]。IDD-8E 与三种抗生素 (Rifampicin (HY-B0272), Lincomycin (HY-117660), Carbenicillin (HY-B0525)) 的多种组合具有协同作用。协同组合有效地减少了抗生素的最小抑制浓度 (MICs)[1]。IDD-8E 可以抑制其他细菌病原体的生长。 A. baumannii, K. pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus faecalis (VRE) and E. coli 的 MIC 值分别是 6.25 µM, 50 µM, 12.5 µM, 12.5 µM 和 50 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IDD-8E 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Formula | C21H20N6O3 |
| Molar Mass | 404.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rakshit M et al. Uncovering the potentiality of quinazoline derivatives against Pseudomonas aeruginosa with antimicrobial synergy and SAR analysis. J Antibiot. 2024 MAR |