| Bioactivity | ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT[1]. |
| Target | IC50: 8.8 μM (ICMT) |
| Name | ICMT-IN-21 |
| CAS | 1310740-69-2 |
| Formula | C22H33NO4S3 |
| Molar Mass | 471.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Majmudar JD, et al. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors. Bioorg Med Chem Lett. 2011 May 1;21(9):2616-20. |
ICMT-IN-21
CAS: 1310740-69-2 F: C22H33NO4S3 W: 471.70
ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farn
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