| Bioactivity | ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure[1][2]. |
| CAS | 124001-41-8 |
| Sequence | {N-Isobutyryl}-His-Trp-Ala-Val-{d-(Ala)}-His-Leu-NHMe |
| Shortening | {N-Isobutyryl}-HWAV-{d-(Ala)}-HL-NHMe |
| Formula | C45H65N13O8 |
| Molar Mass | 916.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Camble R, et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antaconist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sci. 1989;45(17):1521-1527. [2]. Zogovic B, et al. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011;301(5):R1486-R1494. |
ICI 216140
CAS: 124001-41-8 F: C45H65N13O8 W: 916.08
ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stim
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