ICI 162846_product_DataBase

Bioactivity	ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].
In Vivo	ICI 162846 (10 mg/kg，口服，每天两次持续 5 天) 降低了 CFLP 小鼠诱导的 CDU 模型中 CDU 的发生率，并抑制胃酸产生同时伴随组胺分泌增加[2]。 Animal Model:
Name	ICI 162846
CAS	84545-30-2
Formula	C11H17F3N6O
Molar Mass	306.29
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. [2]. Gompertz RH, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3.

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