| Bioactivity | ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1]. |
| Target | EC50: 0.38 μM (KCNQ2/Q3 potassium channel)IC50: 15 μM (KCNQ1) |
| Name | ICA 110381 |
| CAS | 325457-99-6 |
| Formula | C12H8Cl2N2O |
| Molar Mass | 267.11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4. |
ICA 110381
CAS: 325457-99-6 F: C12H8Cl2N2O W: 267.11
ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3
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