ICA-069673_product_DataBase

Bioactivity

ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells[1][2].

Target

IC50: 0.69 μM (KV7.2/7.3), 14.3 μM (KV7.3/7.5)

Invitro

ICA-069673（100 nM-30 μM）剂量依赖性地抑制豚鼠 DSM 分离试纸中的自发相位收缩、药理学诱导的收缩和 10 Hz EFS 诱导的神经诱发收缩[1]。ICA-069673（3 μM，10 μM）抑制豚鼠 DSM 分离条中 20 mM KCl 诱导的 DSM 强直收缩[1]。

Name

ICA-069673

CAS

582323-16-8

Formula

C11H6ClF2N3O

Molar Mass

269.63

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301.

PeptideDB

ICA-069673

CAS: 582323-16-8 F: C11H6ClF2N3O W: 269.63