| Bioactivity | IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model[1][2]. | ||||||||||||
| Target | TAZ | ||||||||||||
| Invitro | IBS008738 (0, 24, 48, 72 h) enhances TAZ expression, with a peak at 24 h[1].IBS008738 (10 μM; 0, 24, 72 h) enhances mRNAs of myogenic markers but not of myofusion markers[1].IBS008738 (10 μM; 24h) enhances mRNAs of IL-10 in C2C12 cells[2]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | IBS008738 (3 nmol) facilitates muscle repair in Cardiotoxin-injected muscles[1].IBS008738 (30 μM, 100 μL) prevents Dexamethasone-induced muscle atrophy[1].IBS008738 (100-μL volume of 30 μM; intramuscular injection; immediately and on day 2 after TBI) diminishes the expression of TNF α and IL-6 but increases that of IL-10 mRNAs in muscles of traumatic brain injury (TBI)[2]. Animal Model: | ||||||||||||
| Name | IBS008738 | ||||||||||||
| CAS | 385425-03-6 | ||||||||||||
| Formula | C22H22N4O2 | ||||||||||||
| Molar Mass | 374.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yang Z, et al. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol Cell Biol. 2014;34(9):1607-1621. [2]. Zou R, et al. TAZ Activator Is Involved in IL-10-Mediated Muscle Responses in an Animal Model of Traumatic Brain Injury. Inflammation. 2017;40(1):100-105. |
IBS008738
CAS: 385425-03-6 F: C22H22N4O2 W: 374.44
IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the as
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