| Bioactivity | IAA65 is a potent T-type calcium channel inhibitor with a IC50 value of 18.9 µM. IAA65 can be used for epilepsy research[1]. |
| Invitro | IAA65 (50 µM; differentiated ND7/23 cells) causes a significant reduction in the current density generated by T-type Ca2+ channel activation[1].IAA65 (50 µM; differentiated ND7/23 cells) alters the steady-state inactivation of Cav3.2 and Cav3.3 T-type Ca2+ channels, which resulted in a significant increase in the inactivation recovery time of the channels[1]. |
| Name | IAA65 |
| Formula | C16H13F6NO2 |
| Molar Mass | 365.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Amaye IJ, et, al. Evaluation of potential anticonvulsant fluorinated N-benzamide enaminones as T-type Ca2+ channel blockers. Bioorg Med Chem. 2022 Jul 1;65:116766. |