Bioactivity | IA9 TFA (human TREM-2 182-190 TFA) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model[1]. |
Name | IA9 TFA |
Sequence | Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala |
Shortening | IFLIKILAA |
Formula | C51H88N10O10.xC2HF3O2 |
Molar Mass | 1001.31 (free acid) |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022;23(16):8857. Published 2022 Aug 9. |